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Design, synthesis and biological evaluation of novel 1α,25-dihydroxyvitamin D3 analogues possessing aromatic ring on 2α-position
- Source :
- Tetrahedron. 61:11253-11263
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- In the present study, we describe the synthesis of new analogues of 1α,25-dihydroxyvitamin D 3 ( 1 ), which possess hydrophobic aromatic ring on the 2α position. Among these analogues, 2α-benzyl analogue showed the highest potency in the affinity for the wild type vitamin D receptor (VDR) and induction of HL-60 cell differentiation as well as transcriptional activity. Affinity for the mutant VDR related to hereditary vitamin D-resistant rickets (R274L) was also examined.
Details
- ISSN :
- 00404020
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Tetrahedron
- Accession number :
- edsair.doi...........fa9ff8c8f7704c2b0f8dd6eec0cc7a07