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Altered alpha adrenergic vasoresponsiveness in a non-cirrhotic portal hypertension model ofE. coliinjection
- Source :
- Journal of Gastroenterology and Hepatology. 22:870-876
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- Background and Aim: Portal hypertension is associated with decreased vascular responsiveness to vasoconstrictors, which may contribute to the hyperdynamic circulation in cirrhosis. Animal models of cirrhosis and portal vein ligation have helped in our understanding of portal hypertension. The etiopathogenesis of non-cirrhotic portal fibrosis (NCPF), a common cause of portal hypertension, is still poorly understood. The aim of this study was to investigate the pathophysiology of NCPF in a rabbit model. Methods: An indwelling cannula was inserted into the gastrosplenic vein of rabbits. Animals were randomly injected with saline (Group I, n = 13) or lipopolysaccharide (Group II, n = 13) from heat killed Escherichia coli at 0, 1, 2, 7, 14 and 28 days. Portal pressure was measured at 3 months and vasoresponsiveness studied in isolated aortic rings in intact and in endothelium-denuded tissues from both groups. Results: In all group II compared with group I animals, the splenic weight (0.89 ± 0.16 vs 0.62 ± 0.1 g, P
- Subjects :
- Aorta
medicine.medical_specialty
Cirrhosis
Hepatology
business.industry
medicine.medical_treatment
Portal venous pressure
Gastroenterology
medicine.disease
Endocrinology
medicine.anatomical_structure
medicine.artery
Internal medicine
Portal fibrosis
Hyperdynamic circulation
Medicine
Portal hypertension
Antihypotensive agent
business
Vein
Subjects
Details
- ISSN :
- 08159319
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Journal of Gastroenterology and Hepatology
- Accession number :
- edsair.doi...........fa9762037af7a4bbc420f590c9bafd3e