Pilot study of glycerol diffusion in ex vivo skin: a comparison of alloxan and streptozotocin diabetes models

Two models of diabetes, such as alloxan and streptozotocin, were used in the study to verify the influence of both on the optical properties and molecular permeability of skin ex vivo. Kinetics of collimated transmittance of control and diabetic skin samples immersed in aqueous 70%-glycerol solution was measured and then processed for estimation of diffusion coefficient of glycerol in skin. As a result, the slower glycerol diffusion rate was observed for both models of diabetes.