Back to Search
Start Over
Comparison of in vivo and in vitro Capability of Complement Fixation by Pemphigus Antibodies
- Source :
- Dermatology. 159:290-294
- Publication Year :
- 1979
- Publisher :
- S. Karger AG, 1979.
-
Abstract
- Using complement immunofluorescence, the capability of complement fixation by bound antibodies in pemphigus lesional skin was compared with circulating intercellular antibodies of complement-fixing type in the same patient. Five lesional skin samples from 6 patients, containing bound IgG, gave positive binding of complement (C3) supplied from fresh guinea pig serum, while only one serum sample showed complement-fixing pemphigus antibodies in the circulation. These results support the view that complement-fixing pemphigus antibodies are rapidly localized to the skin and play a role on the production of acantholysis.
Details
- ISSN :
- 14219832 and 10188665
- Volume :
- 159
- Database :
- OpenAIRE
- Journal :
- Dermatology
- Accession number :
- edsair.doi...........fa519b996b1b21d803510d9bfeaaad67