Imaging Characteristics Associated with Driver Mutations in Patients with Non-Small-Cell Lung Cancer

Aim: The purpose of this study is to better identify imaging characteristics on computed tomography (CT) in patients with non-small-cell lung carcinoma (NSCLC) with known epidermal growth factor receptor (EGFR) mutations, KRAS mutations, and anaplastic lymphoma kinase (ALK) gene rearrangements. Methods: Two hundred fifty-seven patients with a diagnosis of NSCLC and EGFR mutations, KRAS mutations or ALK gene rearrangements were assessed. We retrospectively analyzed the CT characteristics of each cohort. Results: We evaluated 257 patients with NSCLC. One hundred fifty-three patients (59.5%) had EGFR mutations, 54 patients (21.0%) had KRAS mutations, and 50 (19.5%) had ALK gene rearrangements. All mutations were mutually exclusive. Most patients had stage III or IV disease. One hundred twenty-one cases were male, and 136 were female. The mean age was 62.1 years (range29-89). Patients with EGFR mutations tend to have ground grass opacity (GGO), air bronchograms, and lung metastases (p Conclusions: These findings may help to make a proper diagnosis in the current era of molecular targeted therapies. Disclosure: All authors have declared no conflicts of interest.