Recognition of quinolone antibiotics by the multidrug efflux transporter MexB of Pseudomonas aeruginosa

Authors :: Silvia Gervasoni
Giuliano Malloci
Andrea Bosin
Attilio V. Vargiu
Helen I. Zgurskaya
Paolo Ruggerone
Source :: Physical Chemistry Chemical Physics. 24:16566-16575
Publication Year :: 2022
Publisher :: Royal Society of Chemistry (RSC), 2022.
Abstract: Putative binding modes (BMs) of quinolones to the bacterial efflux transporter MexB were identified. Multiple interaction patterns are possible, supporting the hypothesis that substrates oscillate between different BMs with similar affinity.

Subjects :: General Physics and Astronomy
Physical and Theoretical Chemistry

Full Text Access

Tools