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Updated efficacy and safety results from the phase I study of intermittent dosing of the dual MEK/RAF inhibitor, RO5126766 in patients (pts) with RAS/RAF mutated advanced solid tumours

Authors :
Holly Tovey
Vasanthi Prathapan
Udai Banerji
Emma Hall
Nina Tunariu
Alison Turner
Sonia Serrano Fandos
Desamparados Roda Perez
Johann S. de Bono
Maria Jose de Miguel Luken
Hasina Hassam
Timothy A. Yap
Juanita Lopez
Raquel Perez Lopez
Samuel John Harris
Mona Parmar
Source :
Journal of Clinical Oncology. 34:2582-2582
Publication Year :
2016
Publisher :
American Society of Clinical Oncology (ASCO), 2016.

Abstract

2582Background: RO5126766 is a novel MEK inhibitor with functional RAF inhibition. A dose escalation Phase 1 study, comparing 2 intermittent schedules, has previously been reported, with a recommen...

Details

ISSN :
15277755 and 0732183X
Volume :
34
Database :
OpenAIRE
Journal :
Journal of Clinical Oncology
Accession number :
edsair.doi...........f9936b45d963d2f1fe7f9f7bd430572b