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Asymmetric Synthesis of ?-Hydroxy-Estersvia Ester Enolates with Very High Diastereoselectivity
- Source :
- Helvetica Chimica Acta. 69:615-620
- Publication Year :
- 1986
- Publisher :
- Wiley, 1986.
-
Abstract
- The α-hydroxylation of chiral esters of 3-phenylpropionic acid by MoO5·Py·HMPT was optimized to 98% de and 73% yield by systematic variation of the reaction conditions. The addition of at least 3 equiv. of K(sec-BuO) proved to be essential.
- Subjects :
- Reaction conditions
Bicyclic molecule
Stereochemistry
Monoterpene
Organic Chemistry
Enantioselective synthesis
Systematic variation
Biochemistry
Catalysis
Inorganic Chemistry
Hydroxylation
chemistry.chemical_compound
chemistry
Yield (chemistry)
Drug Discovery
Physical and Theoretical Chemistry
Aliphatic compound
Subjects
Details
- ISSN :
- 15222675 and 0018019X
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Helvetica Chimica Acta
- Accession number :
- edsair.doi...........f97653b020103c146f74faf3e2ca53d5
- Full Text :
- https://doi.org/10.1002/hlca.19860690310