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Insights into human genetic variation and population history from 929 diverse genomes
- Publisher :
- American Association for the Advancement of Science (AAAS)
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Abstract
- Genome sequences from diverse human groups are needed to understand the structure of genetic variation in our species and the history of, and relationships between, different populations. We present 929 high-coverage genome sequences from 54 diverse human populations, 26 of which are physically phased using linked-read sequencing. Analyses of these genomes reveal an excess of previously undocumented common genetic variation private to southern Africa, central Africa, Oceania, and the Americas, but an absence of such variants fixed between major geographical regions. We also find deep and gradual population separations within Africa, contrasting population size histories between hunter-gatherer and agriculturalist groups in the past 10,000 years, and a contrast between single Neanderthal but multiple Denisovan source populations contributing to present-day human populations.
- Subjects :
- Population Density
Asia
DNA Copy Number Variations
Whole Genome Sequencing
Genome, Human
Oceania
Racial Groups
Genetic Variation
Hominidae
15. Life on land
Polymorphism, Single Nucleotide
3. Good health
Genetics, Population
Haplotypes
INDEL Mutation
Africa
Animals
Humans
Americas
Phylogeny
Neanderthals
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi...........f947b954bcc3b4afb08aa029892d9cc0