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P155 The microRNA 34 family and its clinical significance in ovarian cancer
- Source :
- Poster exhibition Day 2.
- Publication Year :
- 2019
- Publisher :
- BMJ Publishing Group Ltd, 2019.
-
Abstract
- Introduction/Background The tumor suppressor miR-34 family is transcriptionally induced by p53. Clinical significance of the various miR-34 family members has not been studied in ovarian cancer. Methodology In 228 ovarian cancers and in 19 non-neoplastic fallopian tube samples we analysed miR-34a/b/c expression in relation to clinicopathological characteristics and clinical outcome. Results We found significantly lower levels of miR-34a/b/c in ovarian cancers as compared to control-tissues (P=0.002, P Conclusion Our findings suggest that downregulation of miR-34 family is a crucial part in ovarian cancer development. Low miR-34 levels are linked to a worse overall survival and progression free survival and may indicate a more aggressive disease. Disclosure Nothing to disclose.
- Subjects :
- Oncology
medicine.medical_specialty
business.industry
medicine.disease
law.invention
medicine.anatomical_structure
Downregulation and upregulation
law
Internal medicine
microRNA
medicine
Overall survival
Suppressor
Clinical significance
Progression-free survival
Ovarian cancer
business
Fallopian tube
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Poster exhibition Day 2
- Accession number :
- edsair.doi...........f92a6bf225ef5a48a3e5b90df94fda38
- Full Text :
- https://doi.org/10.1136/ijgc-2019-esgo.216