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Efficacy of using recombinant granulocyte colony-stimulating factor in IVF/ICSI protocols in patients with predicted suboptimal response to controlled ovarian stimulation

Authors :
Cong T. Nguyen
Igor Yu. Kogan
Dariko A. Niauri
Manizha R. Makhmadaliyeva
Lyailya Kh. Dzhemlikhanova
Inna O. Krikheli
Natalya I. Tapilskaya
Ksenia V. Obyedkova
Zarina K. Abdulkadyrova
Toan Thai Tran
Irina D. Mekina
Elena A. Lesik
Evgenia M. Komarova
Maria A. Ishchuk
Alexandr M. Gzgzyan
Source :
Journal of obstetrics and women's diseases. 71:59-70
Publication Year :
2022
Publisher :
ECO-Vector LLC, 2022.

Abstract

BACKGROUND: According to most studies, the efficacy of IVF/ICSI protocols in patients with suboptimal response was significantly lower than in women with normal response. However, methodological approaches optimizing the efficacy of IVF/ICSI protocols in patients with suboptimal response have not been developed. AIM: The aim of this study was to evaluate the efficacy of using recombinant granulocyte colony-stimulating factor in IVF/ICSI protocols in women with predicted suboptimal response to controlled ovarian stimulation. MATERIALS AND METHODS: This prospective study included 102 patients with predicted suboptimal response: treatment group (n = 34) and comparison group (n = 68). Controlled ovarian stimulation was performed according to the standard protocol with gonadotropin-releasing hormone antagonists. Women in treatment group daily received 60 mcg of recombinant granulocyte colony-stimulating factor subcutaneously from the onset of stimulation until the day of human chorionic gonadotropin blood test. The intergroup comparative analysis included clinical-anamnestic data, indicators of hormonal status, ovarian reserve, main characteristics of protocols stimulation, embryological data and the efficacy of IVF/ICSI programs. RESULTS: In the treatment group, the number of retrieval oocytes was higher (8.1 5.3 vs. 4.7 2.6, respectively; p 0.001), and the effective dose of follicle-stimulating hormone preparations was lower than in the comparison group (403.6 351.1 IU vs. 694.3 950.4 IU, respectively; p = 0.013). Besides, the number of mature oocytes (6.8 5.2 vs. 3.7 1.9, respectively; p 0.01), 2PN zygotes (5.1 3.9 vs. 2.8 1.7, respectively; p 0.01), and good quality embryos (3.4 3.3 vs. 1.8 1.5, respectively; p 0.01) were also higher in the treatment group. Сlinical pregnancy rate in women receiving recombinant granulocyte colony-stimulating factor was significantly higher (41.2% vs. 22.1%, respectively; OR 2.47; 95% CI 1.016.03; p 0.05). CONCLUSIONS: Using recombinant granulocyte colony-stimulating factor improves the efficacy of IVF/ICSI protocols in women with predicted suboptimal response.

Subjects

Subjects :
Obstetrics and Gynecology

Details

ISSN :
16839366 and 16840461
Volume :
71
Database :
OpenAIRE
Journal :
Journal of obstetrics and women's diseases
Accession number :
edsair.doi...........f8764aa065f11ce9d42694030bb64739
Full Text :
https://doi.org/10.17816/jowd81947