Role of Antipsychotic Polypharmacotherapy in the Treatment of Schizophrenia

Since the introduction of phenothiazines in the 1950s, clinicians have used anti-psychotics in combination. This practice has previously been declared irrational as traditional antipsychotics were thought to work by similar mechanisms. However, the advent of the atypical antipsychotics provides a cadre of new medications with varying pharmacodynamic profiles. Once again, the potential use of combination antipsychotic therapy is being explored.