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Synthesis, Molecular Modeling, and Biological Evaluation of Novel Chiral Thiosemicarbazone Derivatives as Potent Anticancer Agents
- Source :
- Chirality. 27:177-188
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- A series of new chiral thiosemicarbazones derived from homochiral amines in both enantiomeric forms were synthesized and evaluated for their in vitro antiproliferative activity against A549 (human alveolar adenocarcinoma), MCF-7 (human breast adenocarcinoma), HeLa (human cervical adenocarcinoma), and HGC-27 (human stomach carcinoma) cell lines. Some of compounds showed inhibitory activities on the growth of cancer cell lines. Especially, compound 17b exhibited the most potent activity (IC50 4.6 μM) against HGC-27 as compared with the reference compound, sindaxel (IC50 10.3 μM), and could be used as a lead compound to search new chiral thiosemicarbazone derivatives as antiproliferative agents. Chirality 27:177–188, 2015. © 2014 Wiley Periodicals, Inc.
- Subjects :
- Pharmacology
Molecular model
biology
Chemistry
Stereochemistry
Organic Chemistry
medicine.disease
biology.organism_classification
Catalysis
Analytical Chemistry
HeLa
chemistry.chemical_compound
Drug Discovery
medicine
Adenocarcinoma
Enantiomer
Cytotoxicity
Chirality (chemistry)
Lead compound
Semicarbazone
Spectroscopy
Subjects
Details
- ISSN :
- 08990042
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Chirality
- Accession number :
- edsair.doi...........f856634b592dcf2f7f5f23a4c72c5b39