Back to Search
Start Over
Human antibodies against amyloid β peptide: A potential treatment for Alzheimer's disease
- Source :
- Annals of Neurology. 52:253-256
- Publication Year :
- 2002
- Publisher :
- Wiley, 2002.
-
Abstract
- Naturally occurring antibodies directed against beta-amyloid (Abeta) were detected in intravenous immunoglobulin preparations. After intravenous immunoglobulin treatment in patients with different neurological diseases, total Abeta and Abeta(1-42) in the cerebrospinal fluid was reduced significantly compared with baseline values. In the serum, total Abeta levels increased after intravenous immunoglobulin treatment, whereas no significant change was observed in Abeta(1-42) levels. Antibodies against Abeta were found to be increased in the serum and cerebrospinal fluid after intravenous immunoglobulin treatment. This study provides evidence that intravenous immunoglobulin or purified Abeta antibodies may modify Abeta and Abeta(1-42) levels, suggesting potential utility as a therapy for Alzheimer disease.
- Subjects :
- Chemotherapy
biology
business.industry
medicine.medical_treatment
medicine.disease
Immunoglobulin E
nervous system diseases
Central nervous system disease
Route of administration
Cerebrospinal fluid
Degenerative disease
Neurology
mental disorders
Immunology
biology.protein
Medicine
Neurology (clinical)
Antibody
Alzheimer's disease
business
Subjects
Details
- ISSN :
- 03645134
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Annals of Neurology
- Accession number :
- edsair.doi...........f7f774b32d2af475312ae3cf67e8a066