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An improved method for reductive alkylation of amines using titanium(IV) isopropoxide and sodium cyanoborohydride

Authors :
David J. Leuck
Kenneth A. Cowen
Ronald J. Mattson
Kahnie M. Pham
Source :
The Journal of Organic Chemistry. 55:2552-2554
Publication Year :
1990
Publisher :
American Chemical Society (ACS), 1990.

Abstract

We now report that titanium(IV) isopropoxide is a mild and effective Lewis acid catalyst for the reductive alkylation of amines with ketones and aldehydes in the presence of acid-sensitive functional groups

Details

ISSN :
15206904 and 00223263
Volume :
55
Database :
OpenAIRE
Journal :
The Journal of Organic Chemistry
Accession number :
edsair.doi...........f7d83bad984e7900e702ca07dfae22d2
Full Text :
https://doi.org/10.1021/jo00295a060