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Furanocoumarins from the Roots of Angelica dahurica with Inhibitory Activity against Intracellular Reactive Oxygen Species Accumulation
- Source :
- Journal of Natural Products. 82:2601-2607
- Publication Year :
- 2019
- Publisher :
- American Chemical Society (ACS), 2019.
-
Abstract
- Five new furanocoumarins, dahuribirin H (1), dahuribirin I (2), (2'S)-(+)-5-(2'-hydroxy-3'-methylbut-3'-enyloxy)-8-(3''-methylbut-2″-enyloxy)psoralen (3), (2'R)-(+)-5-(2',3'-epoxy-3'-methylbutoxy)-8-(3″-methylbut-2″-enyloxy)psoralen (4), and 5-methoxy-8-((Z)-4'-(3″-methylbutanoate)-3'-methylbut-2'-enyloxy)psoralen (5), along with 15 known compounds (6-20), were isolated from the roots of Angelica dahurica. The structures of the new compounds were elucidated by spectroscopic analysis, along with electronic circular dichroism calculations and Mosher ester analysis. Compounds 3, 4, 11, 13, and 16 reduced H2O2-induced cell death in HepG2 cells and attenuated reactive oxygen species (ROS) formation without showing cytotoxicity, suggesting that these compounds might have cytoprotective effects against H2O2-induced oxidative damage via ROS scavenging activities.
- Subjects :
- Pharmacology
chemistry.chemical_classification
Programmed cell death
Reactive oxygen species
Circular dichroism
biology
010405 organic chemistry
Chemistry
Stereochemistry
Angelica dahurica
Organic Chemistry
Pharmaceutical Science
Intracellular reactive oxygen species
biology.organism_classification
Inhibitory postsynaptic potential
01 natural sciences
0104 chemical sciences
Analytical Chemistry
010404 medicinal & biomolecular chemistry
chemistry.chemical_compound
Complementary and alternative medicine
Drug Discovery
Molecular Medicine
Cytotoxicity
Psoralen
Subjects
Details
- ISSN :
- 15206025 and 01633864
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- Journal of Natural Products
- Accession number :
- edsair.doi...........f7baa1bc81548ccfcf731b9350cea66e