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CCR2 Inhibition Reduces Tumor‐Associated Myeloid‐Derived Suppressor Cells and Unmasks an α‐PD‐1 Effect to Slow Tumor Progression in Checkpoint Inhibitor Resistant Gliomas

Authors :
James Campbell
Adithya Gopinath
Joseph Flores-Toro
Defang Luo
Rajinder Singh
Jeffrey L. Harrison
Duane Mitchell
Thomas J. Schall
Israel F. Charo
Source :
The FASEB Journal. 33
Publication Year :
2019
Publisher :
Wiley, 2019.

Abstract

INTRODUCTION Immuno-therapy directed at the PD-1/PD-L1 axis has yielded significant treatment advances in various human cancers. However, these outcomes have not extended to glioblastoma (GBM), wit...

Details

ISSN :
15306860 and 08926638
Volume :
33
Database :
OpenAIRE
Journal :
The FASEB Journal
Accession number :
edsair.doi...........f7a4c165694504b484b6dfda77f52c0e