Back to Search
Start Over
Syntheses and Properties of Some Pyrrolo [2, 3-d] pyrimidine Derivatives
- Source :
- Chemical and Pharmaceutical Bulletin. 21:473-477
- Publication Year :
- 1973
- Publisher :
- Pharmaceutical Society of Japan, 1973.
-
Abstract
- The reaction of 6-amino-1, 3-dimethyluracil (I) with phenacyl bromide in DMF gave 1, 3-dimethyl-6-phenylpyrrolo [2, 3-d] pyrimidine-2, 4 (1H, 3H)-dione (II) in high yield. The reaction of I and phenacyl bromide in acetic acid afforded the isomeric 1, 3-dimethy1-5-phenylpyrrolo [2, 3-d] pyrimidine-2, 4 (1H, 3H)-dione as a byproduct besides II. Nitrosation of II gave 1, 3-dimethy1-5-nitroso-6-phenylpyrrolo [2, 3-d] pyrimidine-2, 4 (1H, 3H)-dione (III) along with the corresponding 5-nitro derivative. Ring expansion of III by the Beckmann rearrangement was carried out to give 1, 3-dimethy 1-5-hydroxy-6-phenylpyrimido [4, 5-d]-pyrimidine-2, 4 (1H, 3H)-dione. Denitrosation of III by the action of sulfuric acid was observed.
Details
- ISSN :
- 13475223 and 00092363
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Chemical and Pharmaceutical Bulletin
- Accession number :
- edsair.doi...........f79c9a100bd2b7a0a5a244e1cbc62987