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Autophagy inhibition is the next step in the treatment of glioblastoma patients following the Stupp era
- Source :
- Cancer Gene Therapy. 28:971-983
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- It has now been nearly 15 years since the last major advance in the treatment of patients with glioma. "The addition of temozolomide to radiotherapy for newly diagnosed glioblastoma resulted in a clinically meaningful and statistically significant survival benefit with minimal additional toxicity". Autophagy is primarily a survival pathway, literally self-eating, that is utilized in response to stress (such as radiation and chemotherapy), enabling clearance of effete protein aggregates and multimolecular assemblies. Promising results have been observed in patients with glioma for over a decade now when autophagy inhibition with chloroquine derivatives coupled with conventional therapy. The application of autophagy inhibitors, the role of immune cell-induced autophagy, and the potential role of novel cellular and gene therapies, should now be considered for development as part of this well-established regimen.
- Subjects :
- 0301 basic medicine
Cancer Research
Chemotherapy
Temozolomide
business.industry
medicine.medical_treatment
Autophagy
medicine.disease
Radiation therapy
03 medical and health sciences
Regimen
030104 developmental biology
0302 clinical medicine
Immune system
Chloroquine
030220 oncology & carcinogenesis
Glioma
Cancer research
medicine
Molecular Medicine
business
Molecular Biology
medicine.drug
Subjects
Details
- ISSN :
- 14765500 and 09291903
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Cancer Gene Therapy
- Accession number :
- edsair.doi...........f763f5214b6fdac2a455b11695c97632