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Characterization of acute-on-chronic liver failure and prediction of mortality in Asian patients with active alcoholism
- Source :
- Journal of Gastroenterology and Hepatology. 31:427-433
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- BACKGROUND AND AIMS Alcoholic liver diseases often evolve to acute-on-chronic liver failure (ACLF), which increases the risk of (multi-)organ failure and death. We investigated the development and characteristics of alcohol-related ACLF and evaluated prognostic scores for prediction of mortality in Asian patients with active alcoholism. METHODS A total of 205 patients who were hospitalized with severe alcoholic liver disease were included in this retrospective cohort study, after excluding those with serious cardiovascular diseases, malignancy, or co-existing viral hepatitis. The Chronic Liver Failure (CLIF) Consortium Organ Failure score was used in the diagnosis and grading of ACLF, and the CLIF Consortium ACLF score (CLIF-C ACLFs) was used to predict mortality. RESULTS Patients with ACLF had higher Maddrey discriminant function, model for end-stage liver disease (MELD), and MELD-sodium scores than those without ACLF. Infections were more frequently documented in patients with ACLF (33.3% vs 53.0%; P = 0.004). Predictive factors for ACLF development were systemic inflammatory response syndrome (odds ratio [OR], 2.239; P
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Alcoholic liver disease
Hepatology
business.industry
Gastroenterology
Retrospective cohort study
Odds ratio
medicine.disease
Malignancy
Surgery
Systemic inflammatory response syndrome
03 medical and health sciences
Liver disease
030104 developmental biology
0302 clinical medicine
Internal medicine
Absolute neutrophil count
Medicine
030211 gastroenterology & hepatology
business
Viral hepatitis
Subjects
Details
- ISSN :
- 08159319
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Journal of Gastroenterology and Hepatology
- Accession number :
- edsair.doi...........f752d16cf8c0bce4e4405782b6739391