ChemInform Abstract: Efficient One-Pot Synthesis of N-Containing Heterocycles by Multicomponent Coupling of Silicon-Tethered Diynes, Nitriles, and Isocyanides Through Intramolecular Cyclization of Iminoacyl-Zr Intermediates

Zirconocene-mediated multicomponent coupling of silicon-tethered diynes, nitriles, and isocyanides results in the formation 5-azaindoles and dihydropyrrolo[3,2-c]azepines in dependence of the amount of isocyanides used.