Open-Chain Analogs of LSD II

6-MethyIpyridines substituted in the 3-position, which were quaternized with methyl or ethyl iodide, were condensed under Knoevenagel conditions with 3-indolealde- hyde or with 3-methyl-2-indolealdehyde. The indolylethenylpyridinium iodides thus produced were hydrogenated to the corresponding indolylethylpiperidines. Conversion of the hydrogenation products into acid salts or into quaternary salts provided compounds for pharmacological testing. Some of these are open-chain analogs of LSD.