ChemInform Abstract: PHENYLSELENYLATION OF ARACHIDONIC ACID AS A ROUTE TO INTERMEDIATES FOR LEUKOTRIENE SYNTHESIS. ISOMERIZATION OF CONJUGATED DIENES DURING SELENOXIDE ELIMINATION

Authors :: Jack E. Baldwin
Eric J. Thomas
Neville V. Reed
Source :: Chemischer Informationsdienst. 12
Publication Year :: 1981
Publisher :: Wiley, 1981.
Abstract: Methyl (5 SR , 6 SR )-5-hydroxy-6-phenylselenyleicosa- cis,cis,cis -8,11,14-trienoate ( 8 ), available in two steps from arachidonic acid, undergoes oxidative deselenylation to give selectively either methyl (5 SR )-5-hydroxyeicosa- trans,trans,cis,cis -6,8,11,14-tetraenoate ( 5 ) or its cis -8 isomer ( 6 ), depending upon the reaction conditions.

Subjects :: Reaction conditions
Leukotriene synthesis
chemistry.chemical_compound
Selenoxide elimination
chemistry
Organic chemistry
Arachidonic acid
General Medicine
Oxidative phosphorylation
Conjugated system
Isomerization
Medicinal chemistry

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