ChemInform Abstract: Total Synthesis of (.+-.)-4-Deoxyverrucarol; a New Route to Trichothecanes via Ring Expansion of Small Ring Compounds

Total synthesis of 4-deoxyverrucarol ( 4 ), a trichothecane-type sesquiterpene was achieved via two types of ring expansion reaction, 1,2-rearrangement of 18 and palladium mediated ring expansion reaction of 20 , as key steps providing a new route to trichothecanes.