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Synthesis and cholinesterase inhibitory activity study of Amaryllidaceae alkaloid analogues with N-methyl substitution

Authors :
Petr Jansa
Ivan Barvík
Daniela Hulcová
Eliška Matoušová
Source :
Organic & Biomolecular Chemistry. 20:3960-3966
Publication Year :
2022
Publisher :
Royal Society of Chemistry (RSC), 2022.

Abstract

Amaryllidaceae alkaloid analogues were synthesised, including quaternary ammonium derivatives and N-oxides, and their cholinesterase inhibitory activity was investigated in vitro and by molecular docking.

Details

ISSN :
14770539 and 14770520
Volume :
20
Database :
OpenAIRE
Journal :
Organic & Biomolecular Chemistry
Accession number :
edsair.doi...........f706c3550e6afd297c7b948017dfb13c