ChemInform Abstract: Cytotoxic Cycloartane-Type Triterpenes from Combretum quadrangulare

Authors :: Ikuo Saiki
Arjun H. Banskota
Shigetoshi Kadota
Kim Qui Tran
Yoshihisa Miwa
Yasuhiro Tezuka
Le Kim Phung
Tooru Taga
Source :: ChemInform. 30
Publication Year :: 2010
Publisher :: Wiley, 2010.
Abstract: Seven novel cycloartane-type triterpenes were isolated from Combretum quadrangulare , and their structures were elucidated on the basis of spectral analysis. All these compounds were tested for their cytotoxicity against murine colon 26-L5 carcinoma cells. Methyl quadrangularate B ( 2 ) and methyl quadrangularate D ( 4 ) exhibited potent cytotoxicity having ED 50 values 9.54 and 5.42 μM, respectively.

Subjects :: Terpene
biology
Stereochemistry
Chemistry
Cytotoxic T cell
Spectral analysis
General Medicine
Combretum quadrangulare
biology.organism_classification
Cytotoxicity

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