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Hemorrhagic fevers of viral nature. State of the problem and directions for creating effective means of prevention and treatment
- Source :
- Bulletin of the Russian Military Medical Academy. 22:182-187
- Publication Year :
- 2020
- Publisher :
- ECO-Vector LLC, 2020.
-
Abstract
- An attempt to summarize the data of available information materials on epidemiological aspects, the state and prospects of prevention and treatment of hemorrhagic fevers was. Hemorrhagic fevers of viral nature-zoonotic diseases caused by viruses containing ribonucleic acid are classified into 4 families: Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae. They are spread all over the world, and their pathogens are easily transmitted from person to person, thereby spreading quickly enough beyond the main focus of biological infection. That is why the causative agents of hemorrhagic fevers are regarded as highly contagious biological agents, and agents bioterrorism. Unfortunately, there are currently no effective means of specific prevention and treatment of these infections, and therapeutic measures are limited to the use of symptomatic means. In this regard, the search for substances with pronounced antiviral activity against pathogens of hemorrhagic fevers that can effectively protect against these infections, as well as prevent their occurrence and spread is one of the priority areas of research in modern Infectology, and with the involvement of modern achievements in the field of molecular Virology and genetic engineering. The data obtained in this regard allow a more in-depth understanding of the pathogenesis of hemorrhagic fevers, the mechanisms of interaction of the pathogen with the host at the cellular level, the mechanisms of intracellular replication of viruses, the formation of the hosts response to viral invasion and clinical manifestations of diseases.
- Subjects :
- 0301 basic medicine
biology
business.industry
030106 microbiology
Filoviridae
medicine.disease
Priority areas
biology.organism_classification
Virology
03 medical and health sciences
Ebola Hemorrhagic Fever
Hemorrhagic Fevers
Flaviviridae
030104 developmental biology
medicine
Molecular virology
Bunyaviridae
Lassa fever
business
Subjects
Details
- ISSN :
- 26871424 and 16827392
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Bulletin of the Russian Military Medical Academy
- Accession number :
- edsair.doi...........f6ca502eae530ca64d347a44b4a74a34
- Full Text :
- https://doi.org/10.17816/brmma50557