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A red palm oil diet can reduce the effects of oxidative stress on rat spermatozoa
- Source :
- Andrologia. 44:32-40
- Publication Year :
- 2011
- Publisher :
- Hindawi Limited, 2011.
-
Abstract
- Summary Male Wistar rats (n = 54) received daily supplementation of red palm oil (RPO: 0, 2, 4 ml). Subgroups were subsequently injected with saline, cumene hydroperoxide (cHP, 10 μm) or t-butyl hydroperoxide (tbHP, 20 μm) over a 60-day period after which animals were sacrificed. Epididymal sperm motility, concentration, reactive oxygen species (ROS), lipid peroxidation and enzymes were measured. Sperm concentration, motility, superoxide dismutase (SOD) concentration, glutathione (GSH) and catalase (CAT) activities were significantly lower, while dichlorofluorescein (DCF) and malondialdehyde (MDA) were higher in sperm of hydroperoxide-treated animals compared to controls (P 0.05). RPO supplementation can successfully attenuate the oxidative stress-induced sperm damage due to organic hydroperoxide exposure. We therefore propose that a daily intake of RPO supplement to the diet might be helpful in protecting males against the adverse effects of high ROS in sperm function and help preserve fertility.
- Subjects :
- chemistry.chemical_classification
Reactive oxygen species
biology
Urology
General Medicine
Malondialdehyde
medicine.disease_cause
Sperm
Lipid peroxidation
Superoxide dismutase
Andrology
chemistry.chemical_compound
Endocrinology
chemistry
Biochemistry
Catalase
Cumene hydroperoxide
biology.protein
medicine
Oxidative stress
Subjects
Details
- ISSN :
- 03034569
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Andrologia
- Accession number :
- edsair.doi...........f6583ac3362a43d213c8c4e10205639f