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Understanding and Preventing (N-Nitrosodimethylamine) NDMA Contamination of Medications
- Source :
- Annals of Pharmacotherapy. 54:611-614
- Publication Year :
- 2019
- Publisher :
- SAGE Publications, 2019.
-
Abstract
- N-nitrosodimethylamine (NDMA) is a hepatotoxic agent and carcinogen contaminant in commonly used medications such as valsartan, losartan, irbesartan, and ranitidine. NDMA can be produced during manufacture, introduced from contaminated ingredients procured elsewhere, or introduced from contaminated solvents and catalysts. The Food and Drug Administration has established a maximum dose of NDMA that is permissible per tablet and guidance for manufacturers. However, many unanswered questions about NDMA contamination need rigorous investigation.
- Subjects :
- business.industry
030204 cardiovascular system & hematology
Contamination
Pharmacology
030226 pharmacology & pharmacy
Food and drug administration
Ranitidine
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Irbesartan
Losartan
Valsartan
chemistry
N-Nitrosodimethylamine
medicine
Pharmacology (medical)
business
Carcinogen
medicine.drug
Subjects
Details
- ISSN :
- 15426270 and 10600280
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Annals of Pharmacotherapy
- Accession number :
- edsair.doi...........f657217f81eeed51196e5d9bd0686a1d