ChemInform Abstract: Diastereodivergent Pictet-Spengler Cyclization of Bicyclic N-Acyliminium Ions: Controlling a Quaternary Stereocenter

The diastereoselectivity of the Pictet—Spengler cyclization of bicyclic N-acyliminium ions that contain a 3-azabicyclo[n.3.0]alkane core and an electron-rich π-nucleophilic moiety, such as an indol-2-yl, indol-3-yl, 1-methylpyrrol-2-yl, or 3,5-dimethoxyphenyl group, is examined.