Enantiomerically selective metal complex catalysis. 7. Asymmetric hydrosilylation of imines and oximes on the catalyst [Rh(COD)Cl]2/(S)-phephos

Asymmetric hydrosilylation of acetophenoxime and cyclic and acyclic imines (with subsequent hydrolysis to amines) was investigated using as catalyst a rhodium complex with the chiral phosphinamino ligand (S)-Phephos. With this method the chiral analog of the antidepressant Pyrazidol was synthesized with an optical yield of 73%.