Back to Search
Start Over
Outcome of patients with a history of bilateral retinoblastoma treated for a second malignancy: The Memorial Sloan-Kettering Experience
- Source :
- Medical and Pediatric Oncology. 30:59-62
- Publication Year :
- 1998
- Publisher :
- Wiley, 1998.
-
Abstract
- Background. Patients with bilateral retinoblastoma are well recognized to have high risk of developing a second malignancy, but there are little published data regarding the outcome of these patients following treatment. Patients and Methods. We identified 15 patients with a history of bilateral retinoblastoma who received treatment at Memorial Sloan-Kettering Cancer Center for a newly diagnosed second malignancy. The median age of second tumor occurrence was 18 years (range 10-32 years). Three patients later had a third tumor (18 tumors total). Tumor sites included facial structures in 14 cases and extremities in 4. Histologies included osteosarcoma (5), leiomyosarcoma (5), high-grade spindle cell sarcoma (3), malignant fibrous histiocytoma (3), malignant mesenchymoma (1), and angiosarcoma (1). Results. Nine patients are alive: 7 disease free at a median of 29 months (range 6-214 months) and 2 with residual disease 59 and 148 months post-diagnosis of the second malignancy. Six patients have died at a median of 31 months (range 16-98 months) after diagnosis of the second malignancy. Conclusions. Patients with a history of bilateral retinoblastoma who develop a second malignancy may enjoy extended periods of survival. Aggressive therapy appropriate to the tumor histology and site is indicated.
- Subjects :
- Leiomyosarcoma
Cancer Research
medicine.medical_specialty
Retinoblastoma
business.industry
medicine.medical_treatment
Cancer
medicine.disease
Malignant Mesenchymoma
Surgery
Radiation therapy
Oncology
Pediatrics, Perinatology and Child Health
medicine
Osteosarcoma
Angiosarcoma
Spindle cell sarcoma
business
Subjects
Details
- ISSN :
- 1096911X and 00981532
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Medical and Pediatric Oncology
- Accession number :
- edsair.doi...........f4c7f18e85d8d11a696d11d7918bfada