Practical Synthesis of (3aR, 9bR)-8-Fluoro-7-(perfluoropropan-2-yl)-9b-(phenylsulfonyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole: An Advanced Intermediate to Access the RORγt Inverse Agonist BMT-362265

Authors :: Manivel Pitchai
Anuradha Gupta
Arundutt Silamkoti
Amol G. Dikundwar
Prakash Anjanappa
Srinath Subramaniam
Hemantha Kumar
T. G. Murali Dhar
Ramesh Samikannu
Arun Kumar Gupta
Richard Rampulla
Muthalagu Vetrichelvan
Duraisamy Ramasamy
Arvind Mathur
G. T. Venkatesh Babu
Roshan Y. Nimje
Christuraj Singarayer
Ananta Karmakar
Mushkin Basha
Source :: Organic Process Research & Development. 25:1001-1014
Publication Year :: 2021
Publisher :: American Chemical Society (ACS), 2021.
Abstract: A practical and scalable route to (3aR, 9bR)-8-fluoro-7-(perfluoropropan-2-yl)-9b-(phenylsulfonyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole 10, an advanced intermediate en route to the synthesis o...

Subjects :: Indole test
chemistry.chemical_compound
chemistry
010405 organic chemistry
RAR-related orphan receptor gamma
Stereochemistry
Organic Chemistry
Tetralone
Inverse agonist
Physical and Theoretical Chemistry
010402 general chemistry
01 natural sciences
0104 chemical sciences

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