Formation of Nε-Dnp Lysine during deprotection of Nε-Fmoc lysine in Nim-DNP-histidine-containing peptides

Authors :: Thierry Letailleur
Jamila Najib
André Tartar
Pierrette Maes
Jean-Claude Gesquiere
Source :: Tetrahedron Letters. 34:1921-1924
Publication Year :: 1993
Publisher :: Elsevier BV, 1993.
Abstract: The 2,4-dinitrophenyl group used for histidine side chain protection is not stable during aminolytic removal of Fmoc protecting groups. In the presence

Subjects :: chemistry.chemical_compound
Stereochemistry
Chemistry
Organic Chemistry
Drug Discovery
Lysine
Side chain
Side reaction
Peptide synthesis
chemical and pharmacologic phenomena
Biochemistry
Histidine

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