Continuous inhibition of 11β-hydroxysteroid dehydrogenase type I in adipose tissue leads to tachyphylaxis in humans and rats but not in mice

Authors :: Mikaela Sjöstrand
C. Stacey
P. Ceuppens
A. Gyte
P. Morentin Gutierrez
Jan W. Eriksson
Catarina Nilsson
Brendan Leighton
Joanne deSchoolmeester
John G. Swales
Source :: British Journal of Pharmacology. 172:4806-4816
Publication Year :: 2015
Publisher :: Wiley, 2015.
Abstract: Background and Purpose11-hydroxysteroid dehydrogenase type I (11-HSD1), a target for Type 2 diabetes mellitus, converts inactive glucocorticoids into bioactive forms, increasing tissue concentratio ...

Subjects :: Pharmacology
medicine.medical_specialty
Endocrinology
Internal medicine
medicine
11β hydroxysteroid dehydrogenase
Type 2 Diabetes Mellitus
Adipose tissue
Dehydrogenase
Biology
Tachyphylaxis
hormones, hormone substitutes, and hormone antagonists

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