Feminizing mesenchymomas of the ovary

1. 1. One hundred and thirty-two cases of combined feminizing tumors of the ovary and carcinoma of the uterus were reviewed from the literature. 2. 2. Twenty-eight new cases of feminizing mesenchymoma of the ovary were reported. Eight cases of combined carcinoma and granulosa cell tumor were presented and evaluated. 3. 3. Evidence is offered that granulosa cell tumors, as well as thecomas, present a clinical and pathologic picture of hyperestrogenism. 4. 4. The relationship of estrogen to carcinogenesis in certain target or “receptor” tissues is discussed.