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Association between diabetes and acute lymphocytic leukemia, acute myeloid leukemia, non-Hopkin lymphoma, and multiple myeloma
- Source :
- International Journal of Diabetes in Developing Countries. 42:694-702
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Objective Diabetes increases the risk for cancers. However, whether it is associated with hematologic malignancies is not clear. The present study investigated the association between diabetes and acute lymphocytic leukemia (ALL), acute myeloid leukemia (ML), non-Hopkin lymphoma (NHL), and multiple myeloma (MM). Methods Newly diagnosed adult cancer patients were recruited consecutively from our clinical database. Peoples from a local enterprise were recruited to create a small-scale population-based dataset. We compared the diabetes prevalence between the cancer patients and the local people; an increase in diabetes prevalence in the cancer patients suggests an association between diabetes and the cancer(s). Results We found that the prevalence of diabetes was 19.7%, 21.3%, 12.5%, and 12.0% in ALL, AML, NHL, and MM, respectively, which was higher than that (9.1%) in the local people. Despite that there were more male than female cancer patients, there were more female than male diabetic patients. The increase in diabetes prevalence occurred in ALL and NHL patients aged 18 to 39 years old as well as in AML patients over 40. In MM patients, the increase in diabetes prevalence (18.6%) occurred only in females. Approximately 70% of the diabetic patients were undiagnosed before the diagnosis of the blood cancer. Approximately half of the pre-existing diabetic patients had anti-diabetic treatment, with over 70% of them still had poor glycemic control. Conclusions Our results suggest that diabetes is associated with ALL, AML, NHL, and MM, at least in adult patients.
- Subjects :
- education.field_of_study
medicine.medical_specialty
business.industry
Endocrinology, Diabetes and Metabolism
Population
Cancer
Myeloid leukemia
medicine.disease
Lymphoma
Blood cancer
hemic and lymphatic diseases
Acute lymphocytic leukemia
Diabetes mellitus
Internal medicine
Internal Medicine
medicine
business
education
Multiple myeloma
Subjects
Details
- ISSN :
- 19983832 and 09733930
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- International Journal of Diabetes in Developing Countries
- Accession number :
- edsair.doi...........f3f1f2dc6c58e227feb68c446c7fac8f