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Heparin induces an accumulation of atherogenic lipoproteins during hemodialysis in normolipidemic end-stage renal disease patients
- Source :
- Hemodialysis International. 19:360-367
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- Dyslipidemias may account for the excess of cardiovascular mortality in end-stage renal disease (ESRD). Lipoprotein studies in ESRD patients are usually relative to prehemodialysis samples even if significative changes may occur after dialysis. In this study, we aimed to investigate the effects of ESRD on triglyceride-rich lipoproteins (TRL) subpopulations distribution and acute change following hemodialytic procedures, including the relative contribution of heparin administration. We selected a group of normolipidemic male middle-aged ESRD patients free of any concomitant disease affecting lipoprotein remnant metabolism compared with controls. We separated TRL subfractions according to density and apoE content and evaluated the changes of these particles after hemodialytic procedures with or without heparin. ESRD subjects had higher TRL subfractions, with the exception of apoE-rich particles, lower high-density lipoprotein (HDL) largest subclasses, and a smaller low-density lipoprotein peak particle size than controls. After a hemodialytic standard procedure with heparin, we demonstrated a significant reduction of triglyceride, an increase of HDL-cholesterol levels, and a raise of small very-low-density lipoprotein, intermediate-density lipoproteins (IDL), apoE-rich particles, and non-HDL-cholesterol levels. When hemodialysis was performed without heparin, no significant changes were observed. In the absence of concomitant hyperlipidemic triggers, ESRD patients show significant lipoprotein abnormalities before dialysis, but without any increased remnant particles concentrations. We speculate that hemodialysis, in particular heparin administration during this procedure, leads to a massive atherogenic TRLs production because of the acute stimulation of the dysfunctional lipolytic system not followed by an efficient removal, determining a recurrent lipoprotein remnant accumulation.
- Subjects :
- Apolipoprotein E
medicine.medical_specialty
Triglyceride
business.industry
medicine.medical_treatment
Hematology
Heparin
End stage renal disease
chemistry.chemical_compound
Endocrinology
chemistry
Nephrology
Concomitant
Internal medicine
Medicine
lipids (amino acids, peptides, and proteins)
Hemodialysis
business
Dialysis
medicine.drug
Lipoprotein
Subjects
Details
- ISSN :
- 14927535
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Hemodialysis International
- Accession number :
- edsair.doi...........f36cabb2c320251dc0d48d7aeeea358a