Synthesis of a Pentasaccharide–Oligonucleotide Conjugate: A Novel Antithrombotic Agent

Authors :: W. H. A. Kuijpers
Rogier C. Buijsman
Constant A. A. van Boeckel
Jan E. M. Basten
E. Kuyl-Yeheskiely
Gijsbert A. van der Marel
Jacques H. van Boom
Source :: Chemistry - A European Journal. 2:1572-1577
Publication Year :: 1996
Publisher :: Wiley, 1996.
Abstract: Derivatization of the octadecathymidylate derivative 18 (T18 ODN) containing a free amine function with sulfo-SIAB® gave the corresponding iodoacetyl ODN 21. Conjugation of the latter with the thiol-containing pentasaccharide 17c gave pentasaccharide–ODN conjugate III, which exhibited anti-Xa and antithrombin activities of 173 U mg-1 and 5 U mg-1, respectively.

Subjects :: Antithrombotic Agent
Oligonucleotide
Stereochemistry
Organic Chemistry
Antithrombin
General Chemistry
Combinatorial chemistry
Catalysis
chemistry.chemical_compound
chemistry
medicine
Amine gas treating
Derivatization
Derivative (chemistry)
Conjugate
medicine.drug

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