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O-Arylmandelic acids as highly selective human PPAR α/γ agonists
- Source :
- Bioorganic & Medicinal Chemistry Letters. 13:3185-3190
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- A new class of O-arylmandelic acid PPAR agonists show excellent anti-hyperglycemic efficacy in a db/db mouse model of DM2. These PPARα-weighted agonists do not show the typical PPARγ associated side effects of BAT proliferation and cardiac hypertrophy in a rat tolerability assay.
Details
- ISSN :
- 0960894X
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi...........f27d9bf40d7785a422d3d9005c964c77
- Full Text :
- https://doi.org/10.1016/s0960-894x(03)00702-9