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ChemInform Abstract: Carboxyzincation Employing Carbon Dioxide and Zinc Powder: Cobalt-Catalyzed Multicomponent Coupling Reactions with Alkynes
- Source :
- ChemInform. 47
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Cobalt-catalyzed carboxyzincation reactions employing carbon dioxide and zinc metal powder are developed. By using alkynes as substrates, regio- and stereodefined (Z)-β-zincated acrylates are provided. The corresponding alkenylzinc moiety can be converted to various substituents, affording multisubstituted acrylic acids. Furthermore, by adding electron-deficient alkene to the reaction system, the four-component coupling reactions of alkyne, alkene, CO2, and the Zn atom proceed via carboxyzincation.
Details
- ISSN :
- 09317597
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........f2574d4877a2fb4c8ee1f7ce99937c07