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A New Modeling Approach of Ultrasonic Extraction of Polyphenols from Carob
- Source :
- Journal of Pharmaceutical Innovation. 14:141-151
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- A new approach was proposed to model the extraction kinetics according to the operating parameters. This approach is based on the determination of the critical time tc (a characteristic time which depends on the operating parameters). It is necessary to start by collecting the experimental values of tc from experimental kinetics using the second derivation of extraction yield. Then, a full factorial design 23 is used to model tc as function of studied factors: temperature, solid-liquid ratio and ultrasonic power. The obtained expression of tc was used in second time as the basis of the modeling of extraction kinetics. It made possible to locate the inflection point that separates the two intervals of the extraction. To assure continuity in this point, we changed variable of time for the second phase of extraction and we started fitting from the last calculated point from the first phase. Seven models were tested to fit studied kinetics. A mathematical model was proposed to express tc according to the operating parameters of the studied extraction. Patricelli (composed of two exponential terms) and the exponential models showed the best fitting results for all experiments. Patricelli model fitted very well the first phase of experiments and the exponential model fitted the second phase. This confirms a new coupled washing/diffusion hypothesis of extraction performing in three steps: washing, first diffusion step, and second diffusion step.
- Subjects :
- Extraction (chemistry)
Phase (waves)
Pharmaceutical Science
02 engineering and technology
Function (mathematics)
Factorial experiment
021001 nanoscience & nanotechnology
030226 pharmacology & pharmacy
Exponential function
03 medical and health sciences
0302 clinical medicine
Inflection point
Drug Discovery
Ultrasonic sensor
Diffusion (business)
0210 nano-technology
Biological system
Mathematics
Subjects
Details
- ISSN :
- 19398042 and 18725120
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmaceutical Innovation
- Accession number :
- edsair.doi...........f2554e2bf3dd8288fbcbea33d785cc85