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Laminar flow induces endothelial cell growth arrest through p53 phosphorylation and stabilization
- Source :
- Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. No.99CH37015).
- Publication Year :
- 2003
- Publisher :
- IEEE, 2003.
-
Abstract
- We investigated the role of p53 in mediating the laminar flow-induced growth arrest in endothelial cells (ECs). c-Jun N-terminal kinase (JNK) activity induced by laminar flow is able to phosphorylate p53, an event which leads to the stabilization of p53. We also found that laminar flow caused an increase in the protein level of the exogenous HA-p53 in ECs. This increased p53 level would suppress EC proliferation.
Details
- Database :
- OpenAIRE
- Journal :
- Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. No.99CH37015)
- Accession number :
- edsair.doi...........f241c90984709b330337cfd1829a4f14