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Steroid Receptor RNA Activator Protein (SRAP): A Potential New Prognostic Marker for Estrogen Receptor-Positive/Node-Negative/Younger Breast Cancer Patients

Authors :
Y. Yan
G. Skliris
C. Penner
S. Chooniedass-Kothari
C. Cooper
Z. Nugent
A. Fristenski
M. Hamedani
A. Blanchard
Y. Myal
L. Murphy
E. Leygue
Source :
Cancer Research. 69:2017-2017
Publication Year :
2009
Publisher :
American Association for Cancer Research (AACR), 2009.

Abstract

Purpose: The steroid receptor RNA activator (SRA) is a functional RNA suspected to participate in the mechanisms underlying breast tumor progression. This RNA is also able to encode for a protein, SRAP, whose exact function remains to be determined. Our aim was to assess, in a large breast cancer cohort, whether levels of this protein could be associated with outcome or established clinical parameters.Experimental Design: Following antibody validation, we have assessed SRAP expression by tissue-microarray (TMA) analysis of 372 tumors with known steroid receptor and node status. Clinical follow-up was available for all the corresponding patients. Immunohistochemical scores were independently determined by two investigators and averaged. Statistical analyses were performed using standard univariate and multivariate tests.Results: SRAP levels were significantly (Mann-Whitney rank sum test, P Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 2017.

Details

ISSN :
15387445 and 00085472
Volume :
69
Database :
OpenAIRE
Journal :
Cancer Research
Accession number :
edsair.doi...........f1ef33b8196954c2b4d5c1f46df000e8
Full Text :
https://doi.org/10.1158/0008-5472.sabcs-09-2017