Selective theca cell phosphatase and tensin homolog (tPten) mutant in mice causes PCOS-like morphology and reveals a role of the phosphatidylinositol 3 (PI3) kinase signal pathway in folliculogenesis

OBJECTIVE: Based on our previous finding that ovarian morphology changes with age, we chose the ovarian volume and follicle number with the best sensitivity and specificity to identify polycystic ovaries as a function of age. DESIGN: Case-Control Study. MATERIALS AND METHODS: We reviewed the ultrasound data in women with PCOS (n1⁄4544) and control women (n1⁄4666). PCOS was diagnosed by age 40 years with chronic oligomenorrhea ( 10 mm) or a corpus luteum. ROC curves were examined at each 5 year age interval. RESULTS: A ROC curve was constructed for each 5 year age group. The follicle number with a specificity of at least 75% and sensitivity of at least 68% at all ages and ovarian volume with a specificity of at least 66% and sensitivity of at least 66% at all ages were chosen as cutoffs for determining PCO morphology.