Regional Enteritis Associated with Enterovirus in a Patient with X-Linked Agammaglobulinemia

To the Editor: X-linked agammaglobulinemia is characterized by a profound defect in the production of antibodies of all isotypes; the defect is related to impaired B-lymphocyte differentiation resulting from mutations in the gene for B tyrosine kinase.1 Immunity against viral infections is generally intact in patients with X-linked agammaglobulinemia, with the exception of an unusual susceptibility to enteroviral infection.1 Chronic intestinal inflammation mimicking Crohn's disease has been described in a few patients with X-linked agammaglobulinemia.2,3 Its origin, however, is unknown. A 22-year-old man with X-linked agammaglobulinemia that had been diagnosed at the age of 9 was referred for chronic . . .