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HIV Diagnostics
- Source :
- Infectious Disease Clinics of North America. 33:611-628
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Profound changes in technology have revolutionized laboratory testing for human immunodeficiency virus (HIV) since the first laboratory enzyme immunoassays that detected only immunoglobulin G (IgG) antibodies. Instrumented fourth-generation random-access chemiluminescent assays are now recommended for initial screening because they become reactive in as little as 2 weeks after infection. Using HIV-1 RNA viral load assays after a reactive initial test could confirm infection and provide useful clinical information. Early initiation of antiretroviral therapy and use of preexposure prophylaxis can alter the evolution of biomarkers and assay reactivity, leading to ambiguous test results.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
biology
business.industry
030106 microbiology
Human immunodeficiency virus (HIV)
Chemiluminescent Assays
medicine.disease_cause
Early initiation
Antiretroviral therapy
Immunoglobulin G
03 medical and health sciences
0302 clinical medicine
Infectious Diseases
Immunology
medicine
biology.protein
030212 general & internal medicine
Enzyme immunoassays
Antibody
business
Viral load
Subjects
Details
- ISSN :
- 08915520
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Infectious Disease Clinics of North America
- Accession number :
- edsair.doi...........f1346580bdb3f3629bec00d06e70b279