Metabolism of 14C-Labeled N2, N2, N4, N4 —Tetramethylmelamine in Male House Flies13

In male Musca domestica L., N2,N2,N4,N4-tetramethylmelamine (TMM) was metabolized to N2,N2,N4trimethylmelamine and N2,N4-dimethylmelamine. The absence of the other isomeric trimethyl- and dimethylmelamines among the metabolites indicated that the dimethylamino group was demethylated in preference to the methylamino group. Since more than 80% of the originally injected TMM was recovered as metabolites containing the s-triazine ring, the main metabolic pathway was a demethylation and did not involve ring cleavage.