Aspects of Androgen-Dependent Events as Studied by Antiandrogens

Publisher Summary This chapter discusses the aspects of androgen-dependent events as studied by antiandrogens. The individual studies covered in the chapter are related only insofar as antiandrogens were used in all of them. The chapter focuses on processes of differentiation, studies on the feedback mechanism, and libido and testicular function. It discusses the processes of spermatogenesis that are FSH-dependent. Androgens also play an important role in mammary gland differentiation. It has been known that testicular hormones are responsible for the differences in differentiation of the mammary glands in males and females. All androgen-related sexual differences in mammary gland differentiation can be abolished by the simultaneous administration of antiandrogens. Androgens are also known to be responsible for the differentiation of certain hypothalamic centers into the female or male functional type, and behavioral patterns too are determined hormonally.