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Chlorpromazine-induced lupuslike disease
- Source :
- Journal of the American Academy of Dermatology. 13:109-115
- Publication Year :
- 1985
- Publisher :
- Elsevier BV, 1985.
-
Abstract
- A lupuslike disease with cutaneous manifestations secondary to the use of chlorpromazine (Thorazine) is presented. Skin biopsy specimens demonstrated classic findings consistent with lupus erythematosus and abundant mucin deposition in the cutaneous lesions—a finding not previously reported to occur in drug-induced lupuslike disease. Laboratory and serologic examinations included a positive antinuclear antibody titer, presence of single-stranded deoxyribonucleic acid (DNA), absence of double-stranded DNA, presence of antihistone antibodies, normal complement level, increased IgM level, and prolongation of partial thromboplastin time. These data confirmed our clinical and histologic diagnosis. Cessation of the medication (chlorpromazine) led to resolution of the skin abnormalities. Electron microscopy revealed electrondense drug metabolites in vascular endothelial cells, as well as tubuloreticular inclusion bodies. This is only the second reported case of chlorpromazineinduced lupuslike disease with cutaneous manifestations.
- Subjects :
- Pathology
medicine.medical_specialty
Lupus erythematosus
biology
medicine.diagnostic_test
Anti-nuclear antibody
Increased IgM level
business.industry
Dermatology
medicine.disease
Serology
Skin biopsy
Immunology
medicine
biology.protein
Antibody
business
Chlorpromazine
Partial thromboplastin time
medicine.drug
Subjects
Details
- ISSN :
- 01909622
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Journal of the American Academy of Dermatology
- Accession number :
- edsair.doi...........f093e70f2b88cf3524e55050d16318e8